5-Amino-3-(4-tert-butyl-phenyl)-4-cyano-thiophene-2-carboxylic acid methyl ester → 5-Amino-4-cyano-3-(4-iodo-phenyl)-thiophene-2-carboxylic acid ethyl ester

HRID 1990085Notes

Reaction equation

HRID 1990085 reaction equation
COC(C1SC(N)=C(C#N)C=1C1C=CC(C(C)(C)C)=CC=1)=O.[CH2:23]([O:25][C:26]([C:28]1[S:29][C:30]([N:42]=[N+]=[N-])=[C:31]([C:40]#[N:41])[C:32]=1[C:33]1[CH:38]=[CH:37][C:36]([I:39])=[CH:35][CH:34]=1)=[O:27])[CH3:24]>>[CH2:23]([O:25][C:26]([C:28]1[S:29][C:30]([NH2:42])=[C:31]([C:40]#[N:41])[C:32]=1[C:33]1[CH:38]=[CH:37][C:36]([I:39])=[CH:35][CH:34]=1)=[O:27])[CH3:24]

Participants

3

Reactant 2

HCID 685220375-Amino-3-(4-tert-butyl-phenyl)-4-cyano-thiophene-2-carboxylic acid methyl esterHCID 86612410HCID 86612410, compound

Product 1

HCID 685218625-Amino-4-cyano-3-(4-iodo-phenyl)-thiophene-2-carboxylic acid ethyl ester

Procedure

Using a method substantially in accordance with the method of example 5-amino-3-(4-tert-butyl-phenyl)-4-cyano-thiophene-2-carboxylic acid methyl ester starting with the compound 5-azido-4-cyano-3-(4-iodo-phenyl)-thiophene-2-carboxylic acid ethyl ester gives the title compound.

Sources & evidence

ORD record
ord-a1b1e51bc340405eb2ca6297ef33db56
Source dataset
uspto-grants-2010_01
Patent number
US07642361B2

Reaction notes

Loading…