4-Tert-butyl-phenyl-4-cyano-5-iodo-thiophene-2-carboxylic acid methyl ester → 4-Cyano-3-(2'-cyano-biphenyl-4-yl)-5-iodo-thiophene-2-carboxylic acid ethyl ester

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Using a method substantially in accordance with the method of 3-(4-tert-butyl-phenyl-4-cyano-5-iodo-thiophene-2-carboxylic acid methyl ester starting with the compound, 5-amino-4-cyano-3-(2′-cyano-biphenyl-4-yl)-thiophene-2-carboxylic acid ethyl ester gives the title compound: 1H NMR (400 MHz, CDCl3) δ 7.81-7.46 (m, 8H), 4.22 (q, 2H, J=7.2 Hz), 1.20 (t, 3H, J=7.0 Hz), MS found (M+1)+NH3 502.

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