Dimethylformamide dimethyl acetal → HCID 58873079, compound

Participants

Reaction Steps

Prepare a solution of 3-(4-tert-butyl-phenyl)-4-cyano-5-ethyl-thiophene-2-carboxylic acid amide (270 mg, 0.86 mmol) in 4 mL of dry dimethoxymethyl-dimethyl-amine and heat to reflux under nitrogen. After 1 hour allow 1 mL of solvent to distill out of the reaction, then cool the mixture to room temperature. Dilute the slurry with 10 mL of hexanes, filter off the resulting yellow product and wash with 5 mL hexanes. Vacuum-dry the solid overnight to give 261 mg (82%) of the title compound. MS(ES+, m/e)=368 (M++1).

Provenance & Evidence