Sodium borohydride → HCID 58873178, compound

Participants

Reaction Steps

Add NaBH4 (10 mg, 0.26 mmol) to a solution of 4-cyano-3-(2′-cyano-biphenyl-4-yl)-5-methanesulfonyl-thiophene-2-carboxylic acid ethyl ester (95 mg, 0.22 mmol) in 2 mL of EtOH at 0° C. Remove the ice-bath and stir at room temperature. After 30 minutes add another 10 mg of NaBH4 and stir an additional 30 minutes. Remove the solvents in vacuo and extract the residue with 50 mL of 1/9 MeOHJ CH2Cl2. Evaporate and chromatograph over silica gel (100/0 to 90/10 toluene/EtOAc) to give 44 mg (56%) of the title compound as a white solid. HPLC=94%.

Provenance & Evidence