Ammonia → HCID 68525752, compound

HRID 1990107Notes

Reaction equation

C([O:3][C:4]([C:6]1[S:7][C:8]([C:27]([F:30])([F:29])[F:28])=[C:9]([C:25]#[N:26])[C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:23]#[N:24])=[CH:13][CH:12]=1)=[O:5])C.N>>[C:25]([C:9]1[C:10]([C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]#[N:24])=[CH:15][CH:16]=2)=[C:6]([C:4]([OH:5])=[O:3])[S:7][C:8]=1[C:27]([F:30])([F:28])[F:29])#[N:26]

Participants

Reactant 2

HCID 222Ammonia

HCID 68521838HCID 68521838, compound

Product 1

HCID 68525752HCID 68525752, compound

Procedure

Using a method substantially in accordance with the method of example A-2, starting with the compound from example 4-cyano-3-(2′-cyano-biphenyl-4-yl)-5-trifluoromethyl-thiophene-2-carboxylic acid ethyl ester: 1H NMR (400 MHz, CDCl3) δ 7.57-7.20 (m, 8H), 19F NMR (CDCl3) δ-57.21 ppm (s), MS found (M−1) 397.0 and (M+1) +NH3 416.

Sources & evidence

ORD record: ord-98629899cc1a401cac6ec6c200349640
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07642361B2

Reaction notes

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