HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → HCID 68524574, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Hydrate;hydrochloride | HCID 21885828 | — |
| Reactant | HCID 68521147 | HCID 68521147 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68524574 | HCID 68524574 | 27% |
Reaction Steps
Combine 3-(4-Carboxy-phenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid (0.1 g, 1.0 eq) in CH2Cl2 (5.0 mL) and stir. Add carbonyldiimidazole (2.0 eq). Stir the mixture overnight. Add isopropylamine (1.0 eq) and stir overnight at room temperature. Add 1N HCl water solution. Filter the precipitate to provide the title compound (0.03 g, Yield 27%). MS (ES+, m/e): 361 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642361B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-771ffc24085a4cd4873b4cc189fde795 |
| Source note | uspto-grants-2010_01 |