Formic Acid → HCID 68525343, compound

Participants

Reaction Steps

Add 3-(4-tert-butyl-phenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid amide(0.121 mmol) to 0.5 ml of CH3CN and add 18 mg paraformaldehyde and formic acid (1.59 mmol). Heat for 6 hrs. Concentrate and purify by radial chromatography eluting with ethyl acetate/hexanes to provide the title compound. 1H NMR (400 MHz, CDCl3) δ 7.39 (q, 4H, J=12.0 Hz), 2.80 (s, 3H) and 1.42 (s, 9H).

Provenance & Evidence