Acetonitrile → HCID 178503631, compound

Participants

Reaction Steps

Combine 3-(4-tert-butyl-phenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid amide (0.142 mmol) and 1.5 ml CH3CN with NaN3 (0.43 mmol) and SiCl4 (0.142 mmol) in CH2Cl2 and reflux the mixture for 16 hrs. MS shows desired product and starting material. Conc. to dryness and purification by radial chromatography (Si) on a 1000 micron plate eluting with 5% MeOH/0.5% AcOH/CH2Cl2. Concentrate desired fractions to provide the desired title compound: 1H NMR (400 MHz, CDCl3) δ 7.40 (q, 4H, J=22 Hz), 2.73 (s, 3H), and 1.35 (s, 9H), MS found (M+1) 356.2.

Provenance & Evidence