Methyl 3-(benzyloxy)-5-hydroxybenzoate → 3-{[6-(Azetidin-1-ylcarbonyl)pyridin-3-yl]oxy}-5-[(phenylmethyl)oxy]benzoic acid

HRID 1990293Notes

Reaction equation

HRID 1990293 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:11]=1)[C:5]([O:7]C)=[O:6].[N:20]1([C:24]([C:26]2[CH:31]=[CH:30][C:29](Br)=[CH:28][N:27]=2)=[O:25])[CH2:23][CH2:22][CH2:21]1>>[N:20]1([C:24]([C:26]2[N:27]=[CH:28][C:29]([O:1][C:2]3[CH:3]=[C:4]([CH:9]=[C:10]([O:12][CH2:13][C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:11]=3)[C:5]([OH:7])=[O:6])=[CH:30][CH:31]=2)=[O:25])[CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 7472028Methyl 3-(benzyloxy)-5-hydroxybenzoateHCID 536296172-(Azetidin-1-ylcarbonyl)-5-bromopyridine

Product 1

HCID 536297013-{[6-(Azetidin-1-ylcarbonyl)pyridin-3-yl]oxy}-5-[(phenylmethyl)oxy]benzoic acid

Procedure

The preparations of methyl 3-hydroxy-5-{[phenylmethyl]oxy}benzoate and 2-(azetidin-1-ylcarbonyl)-5-bromopyridine were described earlier.

Sources & evidence

ORD record
ord-77f2110aeeba41449a0eef35ac18efba
Source dataset
uspto-grants-2010_01
Patent number
US07642259B2

Reaction notes

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