HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → N2,N4-bis(3-hydroxyphenyl)-5-phenyl-2,4-pyrimidinediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | N2,N4-bis(3,4-ethylenedioxyphenyl)-5-phenyl-2,4-pyrimidinediamine | HCID 22060379 | — |
| Reactant | N2,N4-bis(3-hydroxyphenyl)-5-bromo-2,4-pyrimidinediamine | HCID 22061141 | — |
| Product | N2,N4-bis(3-hydroxyphenyl)-5-phenyl-2,4-pyrimidinediamine | HCID 22060237 | — |
Reaction Steps
In a manner similar to the preparation of N2,N4-bis(3,4-ethylenedioxyphenyl)-5-phenyl-2,4-pyrimidinediamine, N2,N4-bis(3-hydroxyphenyl)-5-bromo-2,4-pyrimidinediamine and phenylboronic acid were reacted to yield N2,N4-bis(3-hydroxyphenyl)-5-phenyl-2,4-pyrimidinediamine. 1H NMR (CD3OD): δ 7.85 (bs, 1H), 7.54-7.38 (m, 5H), 7.13-7.11 (m, 2H). 7.10-7.04 (m, 3H), 6.97 (dt, 1H, J=1.8 and 8.1 Hz), 6.54 (ddd, 1H, J=1.9, 2.4, and 7.2 Hz), 6.44 (dt, 1H, J=1.8 and 6.0 Hz); LCMS: ret. time: 20.66 min.; purity: 96%; MS (m/e): 371 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642351B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-406b61a5a64247528d8715dcaf1662a4 |
| Source note | uspto-grants-2010_01 |