Ethyl [(phenoxycarbonyl)oxy]acetate → HCID 86610100, compound

Participants

Reaction Steps

A solution of 0.85 g (4.29 mmol) of 2-(6-phenylpyrid-3-yl)ethanamine, prepared in stage 1.2., and of 1.25 g (5.58 mmol) of ethyl [(phenyloxycarbonyl)oxy]acetate (J. Med. Chem., 1999, 42, 277-290) in 40 ml of toluene is heated at 60° C. for 12 hours. The mixture is allowed to return to ambient temperature, the insoluble material is separated by filtration and the filtrate is concentrated under reduced pressure. The residue thus obtained is purifed by chromatography on silica gel, elution being carried out with a 30/70 mixture of ethyl acetate and of cyclohexane.

Provenance & Evidence