HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylvinyltin → 2-Fluoro-4-vinylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Reactant | 4-Bromo-2-fluorobenzonitrile | HCID 736029 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Fluoro-4-vinylbenzonitrile | HCID 21904607 | — |
Reaction Steps
A solution of 4-bromo-2-fluorobenzonitrile (4.92 g, 0.0246 mol), vinyltributyltin (0.78 g, 0.246 mol), and tetrakistriphenylphosphine (0.67 g, 0.58 mmol) in 250 mL of toluene was refluxed under nitrogen overnight. The solvent was evaporated and the residue was flash chromatographed on silica gel with heptane:CH2Cl2 (1:1) to pure CH2Cl2. A colourless oil was obtained that crystallised. Yield: 3.0 g (82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645751B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-22bbbb60448f4922ae166f7ee18c5380 |
| Source note | uspto-grants-2010_01 |