HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Cyano-3-fluorobenzyl methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2-Fluoro-4-(hydroxymethyl)benzonitrile | HCID 11829631 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Cyano-3-fluorobenzyl methanesulfonate | HCID 21904620 | — |
Reaction Steps
2-Fluoro-4-hydroxymethylbenzonitrile (1.3 g, 8.6 mmol; see step (ii) above) was dissolved in 50 mL of CH2Cl2 and cooled on an ice bath. Triethylamine (0.87 g, 8.6 mmol) and methanesulfonyl chloride (0.99 g, 8.7 mmol) were added. After stirring for 1.5 h the reaction mixture was washed with 1M HCl. The organic phase was dried (Na2SO4) and evaporated. The product could be used without purification. Yield of a colourless oil: 1.8 g (92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645751B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-6014d9071b9342bb88d685c63048d561 |
| Source note | uspto-grants-2010_01 |