HCID 23153662, compound → HCID 23153687, compound

HRID 1990771Notes

Reaction equation

HRID 1990771 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]([CH2:14][OH:15])[NH:12][N:13]=2)=[CH:5][CH:4]=1>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[C:11]([CH:14]=[O:15])[NH:12][N:13]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 23153662HCID 23153662, compound

Product 1

HCID 23153687HCID 23153687, compoundYield 46%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
80 °C

Procedure

4.06 g (41.0 mmol) of manganese dioxide was added to a chloroform solution (30 ml) of 1.67 g (8.20 mmol) of the obtained [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]-methanol, and stirred at 80° C. for 8 hours. The reaction liquid was filtered through Celite, and concentrated under reduced pressure to obtain 762 mg (yield: 44%) of 5-(4-methoxyphenyl)-2H-pyrazole-3-carbaldehyde as a white solid.

Workup

  1. customThe reaction liquid
  2. filtrationwas filtered through Celite
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-8e02517935374222b7fd66cf79c257f0
Source dataset
uspto-grants-2010_01
Patent number
US07645756B2

Reaction notes

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