Triethylamine → HCID 23153704, compound

Participants

Reaction Conditions

Reaction Steps

2.09 ml (15.0 mmol) of triethylamine and 1.23 ml (11.0 mmol) of ethyloxalyl chloride were added to a dioxane solution (20 ml) of 2.16 g (10.0 mmol) of 3-hydrazino-6-(4-methoxyphenyl)pyridazine, obtained according to the method described in Journal of Medicinal Chemistry, Vol. 30, pp. 239-249 (1987), and the reaction liquid was stirred at 60° C. for 4 hours. The reaction liquid was concentrated under reduced pressure, and acetic acid (10 ml) was added to the resulting residue and stirred at 120° C. for 2 hours. The reaction liquid was concentrated under reduced pressure, and the resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=1/4) to obtain 615 mg (yield: 21%) of ethyl 6-(4-methoxyphenyl)[1,2,4]triazolo[4,3-b]pyridazine-3-carboxylate.

Provenance & Evidence