Dichloromethane → HCID 135599845, compound

Participants

Reaction Steps

Methylamine/methanol solution (3 ml) was added to a methanol solution of 307 mg (0.97 mmol) of ethyl 6-(4-methoxyphenyl)[1,2,4]triazolo[4,3-b]pyridazine-3-carboxylate, and stirred at room temperature for 14 hours. The reaction liquid was concentrated under reduced pressure, and 2 ml (2.00 mol) of a dichloromethane solution of 1 M boron tribromide was added to a chloroform solution (4 ml) of the resulting residue, and stirred overnight at room temperature. Water was added to the reaction liquid, extracted with chloroform, and the organic layer was washed with saturated saline water. This was dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 65 mg of a crude product of 6-(4-hydroxyphenyl)-N-methyl[1,2,4]triazolo[4,3-b]pyridazine-3-carboxamide.

Provenance & Evidence