Phosphorus oxychloride → HCID 23153698, compound

Participants

Reaction Steps

With cooling with ice, 2.5 ml of phosphorus oxychloride was added to 2.53 g (10.0 mmol) of 1-(4-methoxyphenyl)-3H-pyrido[3,4-d]pyridazin-4-on, and the reaction liquid was stirred under reflux for 6 hours. Water was added to the reaction liquid, extracted with chloroform, and the organic layer was washed with saturated saline water. This was dried with anhydrous sodium chloride, and concentrated under reduced pressure to obtain 2.50 g (yield: 92%) of 4-chloro-1-(4-methoxyphenyl)-pyrido[3,4-d]pyridazine as a brown solid.

Provenance & Evidence