O-Xylene → HCID 23153692, compound

Participants

Reaction Steps

240 mg (4.0 mmol) of formohydrazide and 551 mg (4.0 mmol) of triethylamine hydrochloride were added to a xylene solution (10 ml) of 543 mg (2.0 mmol) of 4-chloro-1-(4-methoxyphenyl)-pyrido[3,4-d]pyridazine, and then stirred under reflux for 2 hours. Water was added to the reaction liquid, extracted with chloroform, and the organic layer was washed with saturated saline water. This was dried with anhydrous sodium sulfate, and then concentrated under reduced pressure to obtain 417 mg of a crude product of 6-(4-methoxyphenyl)-pyrido[3,4-d][1,2,4]triazolo[4,3-b]pyridazine.

Provenance & Evidence