Chloroform → HCID 135599844, compound

HRID 1990788Notes

Reaction equation

HRID 1990788 reaction equation
ClCCl.B(Br)(Br)Br.C(Cl)(Cl)Cl.C[O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[C:21]3[CH:32]=[CH:31][N:30]=[CH:29][C:22]=3[C:23]3[N:24]([CH:26]=[N:27][N:28]=3)[N:25]=2)=[CH:16][CH:15]=1>O>[N:28]1[N:27]=[CH:26][N:24]2[C:23]=1[C:22]1[CH:29]=[N:30][CH:31]=[CH:32][C:21]=1[C:20]([C:17]1[CH:16]=[CH:15][C:14]([OH:13])=[CH:19][CH:18]=1)=[N:25]2

Participants

6

Reactant 4

HCID 6212ChloroformHCID 6344DichloromethaneHCID 25134Boron tribromideHCID 23153692HCID 23153692, compound

Product 1

HCID 135599844HCID 135599844, compoundYield 106.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4.0 ml (4.0 mmol) of a dichloromethane solution of 1 M boron tribromide was added to a chloroform solution (10 ml) of 417 mg of 6-(4-methoxyphenyl)-pyrido[3,4-d][1,2,4]triazolo[4,3-b]pyridazine, and then stirred overnight at room temperature. Water was added to the reaction liquid, extracted with chloroform, and the organic layer was washed with saturated saline water. This was dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 421 mg of 4-(pyrido[3,4-d][1,2,4]triazolo[4,3-b]pyridazin-6-yl)-phenol.

Workup

  1. extractionextracted with chloroform
  2. washthe organic layer was washed with saturated saline water
  3. dry with materialThis was dried with anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-46d74448fe7c49f1bd9d78c72ba6f494
Source dataset
uspto-grants-2010_01
Patent number
US07645756B2

Reaction notes

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