Acetohydrazide → HCID 11350856, compound

HRID 1990789Notes

Reaction equation

[CH:1]1([N:6]2[CH2:11][CH2:10][CH:9]([O:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]4[C:20]5[CH:31]=[CH:30][N:29]=[CH:28][C:21]=5[C:22]5[N:23]([CH:25]=[N:26][N:27]=5)[N:24]=4)=[CH:15][CH:14]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:32](NN)(=O)C>>[CH:1]1([N:6]2[CH2:7][CH2:8][CH:9]([O:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]4[C:20]5[CH:31]=[CH:30][N:29]=[CH:28][C:21]=5[C:22]5[N:23]([C:25]([CH3:32])=[N:26][N:27]=5)[N:24]=4)=[CH:15][CH:14]=3)[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

Reactant 2

HCID 14039Acetohydrazide

HCID 11212155HCID 11212155, compound

Product 1

HCID 11350856HCID 11350856, compound

Procedure

The compound of Example 82 was obtained as a pale yellow solid in the same manner as in Example 2 and Example 79 or according to a method similar to it or according to a combination of the method with an ordinary method, but using 4-chloro-1-(4-methoxyphenyl)-pyrido[3,4-d]pyridazine obtained in Example 79 and acetohydrazide in place of formylhydrazide.

Sources & evidence

ORD record: ord-dc0aec3d4b6741599fe11b391f51821e
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07645756B2

Reaction notes

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