Hydrazine → HCID 23153686, compound

HRID 1990790Notes

Reaction equation

HRID 1990790 reaction equation
[NH2:1][NH2:2].[CH3:3][O:4][C:5]1[N:10]=[CH:9][C:8]([C:11]([C:13]2[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=2[C:15](O)=[O:16])=O)=[CH:7][CH:6]=1>C(O)C>[CH3:3][O:4][C:5]1[N:10]=[CH:9][C:8]([C:11]2[C:13]3[C:14](=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:15](=[O:16])[NH:2][N:1]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 23153702HCID 23153702, compound

Product 1

HCID 23153686HCID 23153686, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

24 ml (121 mmol) of hydrazine was added to an ethanol solution (200 ml) of 28.0 g of 2-[(6-methoxypyridin-3-yl)carbonyl]benzoic acid, and the reaction liquid was stirred at 60° C. for 4 hours. The reaction liquid was concentrated under reduced pressure, and the resulting solid was washed with diethyl ether to obtain 21.50 g (yield: 77%) of 4-(6-methoxypyridin-3-yl)-2H-phthalazin-1-on as a white solid.

Workup

  1. customthe reaction liquid
  2. customThe reaction liquid
  3. concentrationwas concentrated under reduced pressure
  4. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-eec588994129415791885f99e37dbced
Source dataset
uspto-grants-2010_01
Patent number
US07645756B2

Reaction notes

Loading…