Ethanol → HCID 23153667, compound

Participants

Reaction Conditions

Reaction Steps

100 μl (2 mmol) of hydrazine was added to an ethanol solution (10 ml) of 300 mg of 1-chloro-4-(6-methoxypyridin-3-yl)-phthalazine, and the reaction liquid was stirred at 60° C. for 4 hours. The reaction liquid was concentrated under reduced pressure, and formic acid (10 ml) was added to the resulting solid and stirred at 120° C. for 30 minutes. This was concentrated under reduced pressure, aqueous saturated sodium hydrogencarbonate solution was added to the reaction liquid, extracted with chloroform, and the organic layer was washed with saturated saline water. This was dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 141 mg (yield: 51%) of 6-(6-methoxypyridin-3-yl)-[1,2,4]triazolo[3,4-a]phthalazine as a brown solid.

Provenance & Evidence