Hydrogen Bromide → HCID 86607627, compound

Participants

Reaction Steps

A solution of 4-(6-chloro-benzothiazol-2-ylamino)-piperidine-1-carboxylic acid ethyl ester (2.60 g, 7.65 mmol) in hydrobromic acid 48% in water (60 mL) was heated to reflux for 18 h. Removal of hydrobromic acid under reduced pressure and precipitation from ethanol (50 mL) provided 3.26 g (99%) of the title compound which was used directly in the next step. 1H NMR (400 MHz, DMSO): δ 1.69-1.79 (m, 2H), 2.14-2.17 (m, 2H), 3.01-3.09 (m, 2H), 3.32-3.35 (m, 2H), 4.06 (br s, 1H), 7.31 (dd, J=8.4 Hz, J=2.4 Hz, 1H), 7.42 (d, J=8.4 Hz, 1H), 7.88 (d, J=2.4 Hz, 1H), 8.52 (br s, 1H), 8.62 (br s, 1H), 9.00 (br s, 1H). MS (ISP): 266.0 [M−H]−.

Provenance & Evidence