[4-Chloro-3-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-5-ethoxy-phenyl]-methanol → 4-Chloro-3-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-5-ethoxy-benzaldehyde

Participants

Reaction Steps

To a solution of [4-chloro-3-(1,1-dioxo-1λ6-thiomorpholin-4-yl)-5-ethoxy-phenyl]-methanol (0.089 g, 0.28 mmol, 1.0 equiv) in THF (20 mL) was added activated MnO2 (0.242 g, 2.78 mmol, 10.0 equiv). After stirring at rt for 4 h, the reaction mixture was filtered and the solvent removed by evaporation under reduced pressure providing 0.084 g (95%) of the title compound in sufficient quality for the reductive alkylation step. MS (ISP): 318.0 [M+H]+.

Provenance & Evidence