HCID 46882579, compound → HCID 58706344, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of [1-(3-ethoxy-4-methoxy-benzyl)-piperidin-4-yl]-(5-nitro-benzooxazol-2-yl)-amine (1.0 g, 2.35 mmol, 1.0 equiv; example 225) in ethanol (10 mL) was added palladium on activated charcoal 10% (0.1 g, 0.10 mmol, 0.04 equiv), the reaction vessel filled with hydrogen (3.5 bar) and stirred at 60° C. for 18 h. The catalyst was removed by filtration over celite and the solvent removed under reduced pressure yielding 0.79 g (85%) of the title compound which was used directly without further purification. MS (ESI): 397.4 [M+H]+.

Provenance & Evidence