反应详情

To a solution of (2-ethoxy-4′-fluoro-biphenyl-4-yl)-methanol (0.42 g, 1.71 mmol, 1.0 equiv) in dichloromethane (20 mL) was added activated MnO2 (2.97 g, 34.11 mmol, 20.0 equiv). The reaction mixture was stirred vigorously for 3 h at ambient temperature and then filtered through Hyflo Super Cel. The organic phase was concentrated by evaporation under reduced pressure and the crude reaction product purified with column chromatography on silica eluting with hexane/ethyl acetate (4:1) providing 0.33 g (79%) of the title compound. MS (EI): 244.1 [M]+.

1. filtrationfiltered through Hyflo Super Cel
2. concentrationThe organic phase was concentrated by evaporation under reduced pressure
3. customthe crude reaction product
4. custompurified with column chromatography on silica eluting with hexane/ethyl acetate (4:1)