HCID 178474136, compound → HCID 178474135, compound

Participants

Reaction Steps

To a solution of N-[3-(5-hydroxymethyl-4-methyl-1H-imidazol-2-yl)-phenyl]-acetamide (0.064 g, 0.23 mmol, 1.0 equiv) in THF (2 mL) was added activated MnO2 (0.20 g, 2.3 mmol, 10.0 equiv). The reaction mixture was stirred vigorously for 18 h at ambient temperature and then filtered through Hyflo Super Cel. The organic phase was concentrated by evaporation under reduced pressure and the crude reaction product directly used in the following reductive alkylation step without further purification assuming quantitative conversion. MS (ESI): 244.3 [M+H]+.

Provenance & Evidence