N-(2-aminoethyl)acetamide → HCID 20608709, compound

Participants

Reaction Conditions

Reaction Steps

A solution containing (8.1) (85 mg, 0.20 mmol), N-acetylethylene-diamine (201 mg, 1.95 mmol) and DMSO (3 mL) was heated to 100° C. After 1 h the temperature was raised to 130° C. After 3 h the reaction was cooled to room temperature and partitioned between EtOAc and water. The water layer was extracted with EtOAc (2×). The combined EtOAc layers are washed with water, dried over MgSO4, filtered and concentrated. Flash chromatography (SiO2; 1/10 EtOH/CHCl3, Rf 0.25) yielded 73 mg (93%) of a white foamy solid, mp. 196-197° C. 1H NMR (200 MHz, DMSO-d6): δ 1.79 (s, 3H), 3.36 (m, 2H), 3.61 (m, 2H), 5.12 (s, 2H), 6.59 (s, 1H), 6.89-7.09 (m, 3H), 7.20-7.50 (m, 5H), 7.57 (brt, 1H), 8.03 (brt, 1H), 8.39 (m, 2H), 11.81 (br s, 1H); MS (ES): 402.6 (MH+). tR (method A)=3.6 min.

Provenance & Evidence