Hydrochloric Acid → HCID 68565010, compound

Participants

Reaction Steps

27 (126 mg) and dihydroxypropyl amine (273 mg) were stirred in anhydrous DMSO (2 mL) at 80° C. under nitrogen for 4 h. The reaction mixture was cooled to rt and diluted with water (10 mL). The resulting mixture was acidified with 0.5N HCl until a white solid formed (pH≈3.5-4.0). The solid was collected by filtration, washed with cold water, and dried in vacuo. A white solid (131 mg) was obtained in 93% yield. 1H-NMR (200 MHz, DMSO-d6): δ=3.30-3.33 (m, 2H), 3.57-3.60 (m, 2H), 3.65-6.71 (m, 1H), 3.82-3.97 (m, 2H), 7.32 (s, 1H), 7.46-7.50 (m, 3H), 7.55-7.68 (m, 3H), 8.38-8.49 (m, 4H). MS (ES): 468.9 (M++1).

Provenance & Evidence