Hydrochloric Acid → HCID 59121898, compound

Participants

Reaction Steps

(S)-1-[7-Benzene-sulfonyl-4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carbonyl]-4-(2-chlorophenyl)piperidine-4-carbonitrile 31.c (55 mg) was stirred in MeOH and treated with 1 M NaOH aqueous solution at rt under nitrogen for 2 h. The resulting mixture was neutralized with 3M HCl aqueous solution (pH=7). The solvent was then removed in vacuo. The residue was dissolved in DCM+MeOH and charged onto a TLC plate. A white foam (29 mg) was obtained in 67% yield. 1H-NMR (200 MHz, CDCl3+MeOH-d4): δ=1.95-2.20 (m, 2H), 2.50-2.70 (m, 2H), 3.40-3.70 (m, 4H), 3.78-3.95 (m, 3H), 4.65-4.78 (m, 2H), 6.75 (s, 1H), 7.25-7.47 (m, 7H), 8.18-8.23 (m, 4H). MS (ES): 531.0 [MH+].

Provenance & Evidence