1-Benzylpiperazine → HCID 58955121, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-[3-(phenylsulfonyl)-1H-indol-5-yl]ethyl 4-methylbenzenesulfonate (0.16 g, 0.25 mmol) in anhydrous THF (2.5 mL) was added an excess of benzyl piperazine (0.18 mL, 1.02 mmol) and heated to 71° C. for 24 hours. The mixture was partitioned between ethyl acetate and H2O, and the aqueous layer was extracted with ethyl acetate (10 mL). The combined organic layers were washed with 2 M NaOH, (2×15 mL), brine, dried (MgSO4), filtered and concentrated under reduced pressure. Silica gel chromatography (10% EtOH/2N ammonia/dichloromethane) gave the title compound as a light yellow solid (0.11 g, 94%). Mp: 150-153° C. MS (ES+): 460 (M+H).

Provenance & Evidence