Triethyl orthoacetate → HCID 58955096, compound

HRID 1990979Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]([CH3:15])[C:11](=[O:14])[O:12][CH3:13])=[CH:4][C:3]=1[CH2:16][S:17]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)(=[O:19])=[O:18].[C:26](OCC)(OCC)(OCC)[CH3:27]>>[CH3:15][N:10]([CH2:9][CH2:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[NH:1][C:26]([CH3:27])=[C:16]2[S:17]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)(=[O:19])=[O:18])[C:11](=[O:14])[O:12][CH3:13]

Participants

Reactant 2

HCID 66221Triethyl orthoacetate

HCID 59128267HCID 59128267, compound

Product 1

HCID 58955096HCID 58955096, compound

Procedure

The title compound was prepared in substantially the same manner as described in Example 1, step 3 starting from methyl (2-{4-amino-3-[(phenylsulfonyl)methyl]phenyl}ethyl)methylcarbamate (160 mg, 0.44 mmol), and triethyl ortho acetate, and was obtained as a white solid. Mp: 188-191° C., MS (+) 387 (M+H).

Workup

customwas obtained as a white solid

Sources & evidence

ORD record: ord-9aee77c9a6474f698a6fb9ef6f0c73ef
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07645752B2

Reaction notes

Loading…