HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-bromo-1,3-thiazole-4-carboxylate → 1-{2-[4-((trans)-Octahydro-isoquinoline-2-carbonyl)-thiazol-2-yl]-phenyl}-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-bromo-1,3-thiazole-4-carboxylate | HCID 353965 | — |
| Reactant | 2-Acetylphenylboronic acid | HCID 2734309 | — |
| Reactant | (4aS,8aR)-Decahydroquinoline | HCID 6994352 | — |
| Product | 1-{2-[4-((trans)-Octahydro-isoquinoline-2-carbonyl)-thiazol-2-yl]-phenyl}-ethanone | HCID 86613675 | — |
Reaction Steps
1-{2-[4-((trans)-Octahydro-isoquinoline-2-carbonyl)-thiazol-2-yl]-phenyl}-ethanone was synthesized in a similar manner, by the reaction of 2-acetyl-phenyl-boronic acid (Aldrich) with 2-bromo-thiazole-4-carboxylic acid ethyl ester (Combi-Blocks, Inc., San Diego, Calif.) in a Suzuki reaction, followed by hydrolysis and coupling with trans-decahydroquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645773B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-23b1920e62ef403eb12f049b49f9b2f3 |
| Source note | uspto-grants-2010_01 |