1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 59128627, compound

Participants

Reaction Steps

4-Methyl-3-(8-methyl-2-methylsulfanyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-benzoic acid (150 mg, 0.44 mmol) was taken up in 2 mL DMF, and cyclopropylamine (50 mg, 0.88 mmol) was added, followed by EDCI (1.2 g, 0.527 mmol, 1.2 eq.). The reaction mixture was stirred at room temperature for 90 minutes, then partitioned between water and EtOAc. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by preparative thin layer chromatography (EtOAc/hexanes 1:1) to give 25 mg of N-cyclopropyl-4-methyl-3-(8-methyl-2-methylsulfanyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-benzamide MS (M+H)=381.

Provenance & Evidence