Methyl iodide → HCID 59128635, compound

Participants

Reaction Steps

A suspension of potassium carbonate (0.56 g, 4.05 mmol), [5-(5-isobutyl-[1,3,4]oxadiazol-2-yl)-2-methyl-phenyl]-acetic acid (1.01 g, 3.68 mmol) and iodomethane (0.33 mL, 5.26 mmol) in N,N-dimethylformamide (10 mL) was stirred at room temperature for 2 days. The reaction mixture was partitioned between ethyl acetate and water. The combined organic phase was washed with water and brine, dried (magnesium sulfate), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography eluting with 0-40% ethyl acetate in hexanes to give [5-(5-isobutyl-[1,3,4]oxadiazol-2-yl)-2-methyl-phenyl]-acetic acid methyl ester (Yield: 0.54 g, 51%).

Provenance & Evidence