4-Aminotetrahydropyran → HCID 25016748, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8-cyclopentyl-6-{5-(5-isobutyl-[1,3,4]oxadiazol-2-yl)-2-methyl-phenyl}-2-methane-sulfinyl-8H-pyrido[2,3-d]pyrimidin-7-one (0.04 g, 0.08 mmol) and 4-aminotetrahydropyran (0.041 g, 0.40 mmol) in 2-propanol (2 mL) was heated in a microwave reactor at 120° C. for 1 hour. The reaction mixture was cooled and concentrated under reduced pressure. The residue was purified by flash chromatography eluting with 50-70% ethyl acetate in hexanes to give 8-cyclopentyl-6-{5-(5-isobutyl-[1,3,4]oxadiazol-2-yl)-2-methyl-phenyl}-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one (Yield: 16.0 mg, 38%). HRMS (ES+) m/z Calcd for C30H36N6O3. +H [(M+H)+]: 529.2922. Found: 529.2917.

Provenance & Evidence