HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (5-Chloro-2-[(E)-3-[-4-(4-fluorobenzyl)-piperazin-1-yl]-3-oxopropenyl]-phenyl)-carbamic acid tert butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(4-Fluorobenzyl)piperazine | HCID 796563 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-(2-{[(Tert-butoxy)carbonyl]amino}-4-chlorophenyl)prop-2-enoic acid | HCID 11630775 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (5-Chloro-2-[(E)-3-[-4-(4-fluorobenzyl)-piperazin-1-yl]-3-oxopropenyl]-phenyl)-carbamic acid tert butyl ester | HCID 58683691 | 63.3% |
Reaction Steps
(E)-3-(2-tert-Butoxycarbonylamino-4-chlorophenyl)-acrylic acid (150 mg, 0.5 mmol), 1-(4-fluorobenzyl)-piperazine (98 mg, 0.5 mmol) and EDCl.HCl (96 mg, 0.5 mmol) were dissolved in CH2Cl2 and stirred at room temperature for 18 hours. The reaction mixture was purified via chromatography (SiO2, EtOAc) to yield the title compound as a white foam (150 mg, 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645760B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-3a4be4e2c0ad488ab6c04b0598a1cd6d |
| Source note | uspto-grants-2010_01 |