Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 58683689, compound

Participants

Reaction Steps

2-Bromo-4-chlorobenzaldehyde (Boegesoe, Klaus P. et al., J. Med. Chem. (1983), 26(7), 93547) (6.3g, 28.7 mmol) and methoxycarbonylmethylenetriphenylphosphor-ane (10.5 g, 31.6 mmol) were refluxed in toluene (143 ml) for 1 hour. The reaction mixture was cooled and purified via chromatography (SiO2, acetone/hexanes 5/95) to yield the title compound as colorless crystals (4.8 g, 61%).

Provenance & Evidence