Di-tert-butyl dicarbonate → HCID 58683692, compound

Participants

Reaction Steps

(E)-3-(2-Amino-5-chlorophenyl)-acrylic acid methyl ester (Gonzalez-Zamora, Eduardo et al Chem. Comm. (2001), (17), 1684-1685.) (1.7 g, 8.0 mmol) in THF (6.5 ml) was combined with (BOC)2O (6.98 g9 32.0 mmol) and refluxed for 4 hours. THF was evaporated and the residue purified via chromatography (SiO2, acetone/hexanes 5/95) followed by recrystallisation from hexanes to yield the title compound as yellow crystals (1.8 g; 72%).

Provenance & Evidence