HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 58683727, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-(4-Fluorobenzyl)-3-methylpiperazine | HCID 10703584 | — |
| Reactant | HCID 58683732 | HCID 58683732 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58683727 | HCID 58683727 | 74% |
Reaction Steps
(E)-3-(2-tert-Butyloxycarbonylamino-5chlorophenyl)-acrylic acid (1.0 g, 3.36 mmol) and EDCl.HCl (645 mg, 3.36 mmol) and racemic 1-(4-fluorobenzyl)-3-methyl-piperazine (Bolos, Jordi et al. J. Med. Chem. (1996), 39(15), 2962-2970) (770 mg, 3.7 mmol) were dissolved in CH2Cl2 (34 ml) and stirred at room temperature for 4 hours. The reaction mixture was purified via chromatography (SiO2, EtOAc/hexanes 1/1) to yield the title compound as colorless foam (1.2 g, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645760B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-560a3fe57ec64e0bac1e53e315c1bb39 |
| Source note | uspto-grants-2010_01 |