Hydrochloric Acid → HCID 58683742, compound

Participants

Reaction Steps

(E)-3-(7-Nitroquinolin-6-yl)-acrylic acid methyl ester (470 mg, 1.82 mmol) in EtOH (9 ml) was treated with 2N NaOH (1.38 ml; 2.76 mmol) for 30 min. at 50° C. The reaction mixture was acidified with 2N HCl to pH 3.5 and extracted with EtOAc/EtOH (10/1) three times. The combined organic phases were washed with water, dried over Na2SO4 and evaporated to dryness to yield the title compound as colorless crystals (430 mg; 90%).

Provenance & Evidence