反应详情

(E)-3-(2-Amino-4-chloro-5-methoxyphenyl)-acrylic acid ethyl ester (250 mg; 0.98 mmol) in pyridine (2 ml) was treated with methanesulfonyl chloride (0.15 ml; 2 mmol) for 15 min. at room temperature. The reaction mixture was poured on water and extracted with TBME three times. The combined organic phases were evaporated to dryness and purified via chromatography (SiO2; acetone/hexanes 2/8) to yield the title compound as slightly yellow crystals (216 mg; 66%)

1. additionThe reaction mixture was poured on water
2. extractionextracted with TBME three times
3. customThe combined organic phases were evaporated to dryness
4. custompurified via chromatography (SiO2; acetone/hexanes 2/8)