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(E)-3-(4Chloro-2-methanesulfonylamino-5-methoxyphenyl)-acrylic acid ethyl ester (320 mg; 0.96 mmol) was refluxed in 2N NaOH/EtOH 1/10 for 10 min. The resulting suspension was cooled to 0° C., filtered, taken up in water and acidified with 2N HCl and extracted with TBME three times. The combined organic phases were dried over Na2SO4 and evaporated to dryness to yield the title compound as yellowish crystals (114 mg; 39%).

1. filtrationfiltered
2. extractionextracted with TBME three times
3. dry with materialThe combined organic phases were dried over Na2SO4
4. customevaporated to dryness