Sodium Carbonate → HCID 68536089, compound

Participants

Reaction Steps

(E)-3-[4Chloro-5-(2-methoxyethoxy)-2-nitrophenyl]-acrylic acid methyl ester (910 mg; 2.88 mmol) was dissolved in MeOH (160 ml)/HClconc (50 ml). SnCl2 (7.4 g; 39 mmol) was added and the reaction mixture stirred for 1 h at room temperature, poured on saturated Na2CO3 and extracted with TBME three times. The combined organic phases were dried over Na2SO4 and evaporated to dryness to yield the intermediate (E)-3-[2-amino-4-chloro-5-(2-methoxyethoxy)-phenyl]acrylic acid methyl ester (740 mg; 90%).

Provenance & Evidence