1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 10478659, compound

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Reaction Steps

(R)-3-Ethyl-1-(4-fluorobenzyl)-piperazine (88.8 mg, 0.4 mmol), EDCI (152 mg, 0.8 mmol), HOBT (110 mg, 0.8 mmol) and (E)-3-(4-Chloro-2-ureido-phenyl-acrylic acid (96 mg, 0.4 mmol) were dissolved in 5 ml DCM and this mixture was stirred at room temperature over night. The mixture was diluted with 50 ml DCM and extracted 3 times with water and once with saturated sodium chloride solution. The title compound was purified by chromatography (SiO2, ethyl acetate/MeOH/NH3conc, 98/2/0.2) and was isolated as pale solid (60 mg, 34%)

Provenance & Evidence