1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 9980976, compound

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Reaction Steps

(E)-3-(2-Acetylamino-4-chloro-phenyl)-acrylic acid (2.2 g, 9.36 mmol), EDCI (3.6 g, 18.7 mmol); HOBT (2.5 g, 18.7 mmol) and 2.1 g (9.36 mmol) [(S)-4-(4-Fluorobenzyl)-piperazin-2-yl]-methanol were dissolved in 200 ml THF and stirred for 20 hours at room temperature. This mixture was then extracted 3 times with water and once with saturated sodium chloride solution. The title compound was purified by chromatography (SiO2, ethyl acetate/MeOH/NH3conc. 90/10/1) and was isolated as a pale solid (1.6 g, 39%)

Provenance & Evidence