Sodium Hydroxide → HCID 68538254, compound

HRID 1991090Notes

Reaction equation

HRID 1991090 reaction equation
[Br:1][C:2]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([Cl:11])=[CH:5][C:3]=1[NH2:4].[O-:12][C:13]#[N:14].[K+].[OH-].[Na+]>C(O)(=O)C.O>[Br:1][C:2]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([Cl:11])=[CH:5][C:3]=1[NH:4][C:13]([NH2:14])=[O:12]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 11378442Potassium cyanateHCID 451567062-Bromo-5-chloro-4-methoxybenzenamine

Product 1

HCID 68538254HCID 68538254, compoundYield 29%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

To a solution of 2.0 g (8.5 mmol) 2-bromo-5-chloro-4-methoxy aniline in 20 ml acetic acid and 20 ml water was added in small portions 1.37 g (17 mmol) potassium cyanate. The mixture was stirred at r.t. for 2 hours, neutralized with 2N NaOH and the product was extracted into ethyl acetate. Removal of the solvent and crystallization with ether gave 0.69 g (29%) of the desired urea.

Workup

  1. extractionthe product was extracted into ethyl acetate
  2. customRemoval of the solvent and crystallization with ether

Sources & evidence

ORD record
ord-1c8b40e0e0714bfc88ae042bc31a6058
Source dataset
uspto-grants-2010_01
Patent number
US07645760B2

Reaction notes

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