Potassium Carbonate → HCID 59128677, compound

Participants

Reaction Steps

According to the general procedure using: 27 (60 mg, 0.174 mmol), (bromomethyl)cyclopropane (101 μL, 1.05 mmol), K2CO3 (241 mg, 1.74 mmol) and n-Bu4NI (6.4 mg, 17 μmol) in acetone (4.0 mL) were heated at reflux overnight. Standard workup and purification by PTLC using 5% MeOH in CH2Cl2 gave 28s as a clear oil (41 mg, 59%); 1H NMR (400 MHz, CDCl3) δ-0.066 (s, 9H), 0.38 (q, J=4.68 Hz, 2H), 0.68 (m, 2H), 0.91 (m, 2H), 1.31 (m, 1H), 3.55 (t, J=8.3 Hz, 2H), 3.89 (d, J=7.0 Hz, 2H), 3.98 (s, 3H), 5.64 (s, 2H), 7.36 (s, 1H), 7.51 (d, J=2.6 Hz, 1H), 7.58 (s, 1H), 7.74 (d, J=0.3 Hz, 1H), 8.16 (d, J=2.6 Hz, 1H).

Provenance & Evidence