Potassium Carbonate → HCID 68608716, compound

Participants

Reaction Steps

According to the general procedure using: 27 (60 mg, 0.174 mmol), (bromomethyl)cyclohexane (146 μL, 1.05 mmol), K2CO3 (241 mg, 1.74 mmol) and n-Bu4M (6.4 mg, 17 μmol) in acetone (4.0 mL) were heated at reflux for 24 h. Standard workup and purification by PTLC using 80% AcOEt in hexane gave 28t as a clear oil (40 mg, 52%); 1H NMR (400 MHz, CDCl3) δ-0.059 (s, 9H), 0.93 (t, J=8.2 Hz, 2H), 1.09 (dq, J=12.2 Hz, J=3.3 Hz, 2H), 1.17-1.40 (m, 2H), 1.65-1.95 (m, 7H), 3.56 (t, J=8.3 Hz, 2H), 3.84 (d, J=6.3 Hz, 2H), 3.99 (s, 3H), 5.64 (s, 2H), 7.38 (s, 1H), 7.49 (d, J=2.6 Hz, 1H), 7.59 (s, 1H), 7.75 (d, J=0.3 Hz, 1H), 8.13 (d, J=2.6 Hz, 1H).

Provenance & Evidence