3-(Furan-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine → 3-(1h-Pyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridin-5-amine

Participants

Reaction Steps

Inhibitor 53 was synthesized following the method described for preparation of 48 using 51 (150 mg, 0.28 mmol). The reaction mixture was concentrated to dryness in vacuum and separated by means of LCMS (column LUNA 10 μ C18(2) 00G-4253-V0 250×50 mm) using water—MeCN (0.1% AcOH) as eluent (in gradient; flow 80 mL/min) to afford 53 (6.07 mg, 11%). 1H NMR (400 MHz; CDCl3+3 drops of CD3OD) δ 7.26 (s, 1H), 7.66 (s, 2H), 8.54 (d, J=1.9 Hz, 1H), 8.68 (d, J=1.9 Hz, 1H); MS (ES) m/z 241 (MH++MeCN).

Provenance & Evidence